Molekylär epidemiologi

Målet med vår forskning är att förstå orsaker och konsekvenser till diabetes och hjärtkärlsjukdom, att identifiera nya biomarkörer och livsstilsfaktorer samt ta fram nya metoder för sjukdomsövervakning.

Forskargruppen kombinerar information från stora befolkningsstudier med moderna molekylära mätmetoder för att studera folksjukdomar såsom diabetes och hjärtsjukdom. De mätmetoder vi använder inkluderar variationer i vårt DNA, cirkulerande biomarkörer som proteiner eller metaboliter, tarmflora, eller utseende eller funktion som kan skattas med bilddiagnostiska metoder som ultraljud eller magnetkameraundersökning. Inom vårt fält drar vi ofta nytta av möjligheten av att kombinera data från flera olika källor, allt ifrån uppgifter i olika register till data från olika typer av undersökningar av försökspersoner till data från covid-19 övervakning.

Vårt mål är att skapa en kreativ och internationellt ledande forskningsmiljö som med hjälp av molekylära metoder ökar förståelsen av sjukdomsmekanismer, hittar nya behandlingsstrategier och förbättrar prediktion av hjärt-kärlsjukdomar och relaterade tillstånd. Dessutom, till följd av covid-19-pandemin, strävar gruppen efter att utveckla nya metoder för att övervaka smittspridning av sjukdomar och försöker etablera ett systematiskt tillvägagångssätt för ökat säkerhet av vaccination i framtida kriser.

Gruppmedlemmar

Forskningsledare: Tove Fall

Se enhetens sida i personal- och organisationskatalogen.

Publikationer

Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS

Baldanzi, Gabriel; Sayols-Baixeras, Sergi; Ekblom-Bak, Elin; Ekblom, Örjan et al.

Ingår i EBioMedicine, 2024
- DOI för Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
- Ladda ner fulltext (pdf) av Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.

Ghosh, Nilanjana; Lejonberg, Carl; Czuba, Tomasz; Dekkers, Koen et al.

Ingår i Scientific Reports, s. 8933, 2024
- DOI för Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, Ken; Giedraitis, Vilmantas; Ingelsson, Martin; Lind, Lars et al.

Ingår i Nature, s. 347-357, 2024
- DOI för Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
- Ladda ner fulltext (pdf) av Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Major cardiovascular events and death in parents of children with type 1 diabetes: a register-based matched cohort study in Sweden.

Kennedy, Beatrice; Wernroth, Mona-Lisa; Batra, Gorav; Hammar, Ulf et al.

Ingår i Diabetologia, 2024
- DOI för Major cardiovascular events and death in parents of children with type 1 diabetes: a register-based matched cohort study in Sweden.
Markers of imminent myocardial infarction

Gustafsson, Stefan; Lampa, Erik; Jensevik, Karin; Butterworth, Adam S. et al.

Ingår i Nature Cardiovascular Research, 2024
- DOI för Markers of imminent myocardial infarction
- Ladda ner fulltext (pdf) av Markers of imminent myocardial infarction
Predicting COVID-19 hospitalizations: The importance of healthcare hotlines, test positivity rates and vaccination coverage

van Zoest, Vera; Lindberg, Karl; Varotsis, Georgios; Osei, Frank Badu et al.

Ingår i Spatial and Spatio-temporal Epidemiology, 2024
- DOI för Predicting COVID-19 hospitalizations: The importance of healthcare hotlines, test positivity rates and vaccination coverage
- Ladda ner fulltext (pdf) av Predicting COVID-19 hospitalizations: The importance of healthcare hotlines, test positivity rates and vaccination coverage
Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications

Engström, G.; Lampa, Erik; Dekkers, Koen; Lin, Yi-Ting et al.

Ingår i Eur J Epidemiol, 2024
- DOI för Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Response by Sayols-Baixeras et al to Letter Regarding Article, "Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort".

Sayols-Baixeras, Sergi; Dekkers, Koen; Orho-Melander, Marju; Fall, Tove

Ingår i Circulation, 2024
- DOI för Response by Sayols-Baixeras et al to Letter Regarding Article, "Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort".
Sociodemographic characteristics and COVID-19 testing rates: spatiotemporal patterns and impact of test accessibility in Sweden

Kennedy, Beatrice; Varotsis, Georgios; Hammar, Ulf; Nguyen, Diem et al.

Ingår i European Journal of Public Health, s. 14-21, 2024
- DOI för Sociodemographic characteristics and COVID-19 testing rates: spatiotemporal patterns and impact of test accessibility in Sweden
- Ladda ner fulltext (pdf) av Sociodemographic characteristics and COVID-19 testing rates: spatiotemporal patterns and impact of test accessibility in Sweden
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.

Gong, Tong; Karlsson, Robert; Yao, Shuyang; Magnusson, Patrik K E et al.

Ingår i G3, 2024
- DOI för The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.
A machine learning based approach to identify carotid subclinical atherosclerosis endotypes

Chen, Qiao Sen; Bergman, Otto; Ziegler, Louise; Baldassarre, Damiano et al.

Ingår i Cardiovascular Research, s. 2594-2606, 2023
- DOI för A machine learning based approach to identify carotid subclinical atherosclerosis endotypes
Adipokines and risk of rheumatoid arthritis: A two-sample multivariable Mendelian randomisation study

Vasileiadis, Georgios K.; Sayols-Baixeras, Sergi; Zhao, Sizheng Steven; Fatima, Tahzeeb et al.

Ingår i PLOS ONE, 2023
- DOI för Adipokines and risk of rheumatoid arthritis: A two-sample multivariable Mendelian randomisation study
- Ladda ner fulltext (pdf) av Adipokines and risk of rheumatoid arthritis: A two-sample multivariable Mendelian randomisation study
Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort

Palm, Andreas; Theorell-Haglöw, Jenny; Isakson, Johan; Ljunggren, Mirjam et al.

Ingår i BMJ Open, 2023
- DOI för Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort
- Ladda ner fulltext (pdf) av Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort
Association of physical activity with high-density lipoprotein functionality in a population-based cohort: the REGICOR study

Viadas, Raul; Toloba, Andrea; Fernandez, Isabel; Sayols-Baixeras, Sergi et al.

Ingår i Revista Española de Cardiología, s. 86-93, 2023
- DOI för Association of physical activity with high-density lipoprotein functionality in a population-based cohort: the REGICOR study
Cardiovascular disease-linked plasma proteins are mainly associated with lung volume

Rydell, Andreas; Nerpin, Elisabet; Zhou, Xingwu; Lind, Lars et al.

Ingår i ERJ Open Research, 2023
- DOI för Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
- Ladda ner fulltext (pdf) av Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis

Velasquez, Ilais Moreno; Malarstig, Anders; Baldassarre, Damiano; Borne, Yan et al.

Ingår i CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2023
- DOI för Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors JACC State-of-the-Art Review

Figtree, Gemma A.; Vernon, Stephen T.; Harmer, Jason A.; Gray, Michael P. et al.

Ingår i Journal of the American College of Cardiology, s. 1343-1359, 2023
- DOI för Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors JACC State-of-the-Art Review
Diminishing benefits of urban living for children and adolescents' growth and development

Mishra, Anu; Lin, Yi-Ting; Lind, Lars; Sundström, Johan et al.

Ingår i Nature, s. 874-883, 2023
- DOI för Diminishing benefits of urban living for children and adolescents' growth and development
- Ladda ner fulltext (pdf) av Diminishing benefits of urban living for children and adolescents' growth and development
Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women

Liu, A.; Akimova, E. T.; Ding, X.; Jukarainen, S. et al.

Ingår i Nature Human Behaviour, 2023
- DOI för Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women
- Ladda ner fulltext (pdf) av Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women
Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study

Donovan, Killian; Herrington, William G.; Pare, Guillaume; Pigeyre, Marie et al.

Ingår i American Society of Nephrology. Clinical Journal, s. 17-27, 2023
- DOI för Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study
- Ladda ner fulltext (pdf) av Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Williamson, Alice; Norris, Dougall M; Yin, Xianyong; Broadaway, K Alaine et al.

Ingår i Nature Genetics, s. 973-983, 2023
- DOI för Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Guidelines for microbiome studies in renal physiology

Muralitharan, Rikeish R.; Snelson, Matthew; Meric, Guillaume; Coughlan, Melinda T. et al.

Ingår i American Journal of Physiology - Renal Physiology, 2023
- DOI för Guidelines for microbiome studies in renal physiology
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila et al.

Ingår i Nature Genetics, s. 1448-+, 2023
- DOI för GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
- Ladda ner fulltext (pdf) av GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study.

Grahnemo, Louise; Nethander, Maria; Coward, Eivind; Gabrielsen, Maiken Elvestad et al.

Ingår i Nature Communications, 2023
- DOI för Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study.
- Ladda ner fulltext (pdf) av Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study.
Large-Scale Metabolomics and the Incidence of Cardiovascular Disease

Lind, Lars; Fall, Tove; Ärnlöv, Johan; Elmståhl, Sölve et al.

Ingår i Journal of the American Heart Association, 2023
- DOI för Large-Scale Metabolomics and the Incidence of Cardiovascular Disease
- Ladda ner fulltext (pdf) av Large-Scale Metabolomics and the Incidence of Cardiovascular Disease
Loci for insulin processing and secretion provide insight into type 2 diabetes risk.

Broadaway, K Alaine; Yin, Xianyong; Williamson, Alice; Parsons, Victoria A et al.

Ingår i American Journal of Human Genetics, s. 284-299, 2023
- DOI för Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study

Baldanzi, Gabriel; Sayols-Baixeras, Sergi; Theorell-Haglöw, Jenny; Dekkers, Koen F. et al.

Ingår i Chest, s. 503-516, 2023
- DOI för OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
- Ladda ner fulltext (pdf) av OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis

Dunder, Linda; Salihovic, Samira; Varotsis, Georgios; Lind, P. Monica et al.

Ingår i Environment International, 2023
- DOI för Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
- Ladda ner fulltext (pdf) av Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study

Ostgren, Carl Johan; Otten, Julia; Festin, Karin; Angeras, Oskar et al.

Ingår i Cardiovascular Diabetology, 2023
- DOI för Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study
- Ladda ner fulltext (pdf) av Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study
Prevalence of Charcot Foot in Subjects With Diabetes: A Nationwide Cohort Study

Tsatsaris, Georgios; Rajamand Ekberg, Neda; Fall, Tove; Catrina, Sergiu-Bogdan

Ingår i Diabetes Care, 2023
- DOI för Prevalence of Charcot Foot in Subjects With Diabetes: A Nationwide Cohort Study
Sociodemographic characteristics and COVID-19 testingrates: spatiotemporal patterns and impact of testaccessibility in Sweden

Kennedy, Beatrice; Varotsis, Georgios; Hammar, Ulf; Nguyen, Diem et al.

Ingår i European Journal of Public Health, 2023
Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort

Sayols-Baixeras, Sergi; Dekkers, Koen; Baldanzi, Gabriel; Jönsson, Daniel et al.

Ingår i Circulation, s. 459-472, 2023
- DOI för Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
- Ladda ner fulltext (pdf) av Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes

Titova, Olga E.; Baron, John A.; Fall, Tove; Michaëlsson, Karl et al.

Ingår i American Journal of Preventive Medicine, s. 60-66, 2023
- DOI för Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
- Ladda ner fulltext (pdf) av Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
The metabolic profile of waist to hip ratio-A multi-cohort study

Lind, Lars; Ahmad, Shafqat; Elmståhl, Sölve; Fall, Tove

Ingår i PLOS ONE, 2023
- DOI för The metabolic profile of waist to hip ratio-A multi-cohort study
- Ladda ner fulltext (pdf) av The metabolic profile of waist to hip ratio-A multi-cohort study
A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections

Tängdén, Thomas; Gustafsson, Stefan; Rao, Abhiram S.; Ingelsson, Erik

Ingår i Scientific Reports, 2022
- DOI för A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections
- Ladda ner fulltext (pdf) av A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas, Shweta; Gustafsson, Stefan; Lind, Lars; Ingelsson, Erik et al.

Ingår i American Journal of Human Genetics, s. 1366-1387, 2022
- DOI för A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.

Bonander, Carl; Stranges, Debora; Gustavsson, Johanna; Almgren, Matilda et al.

Ingår i European Journal of Public Health, s. 799-806, 2022
- DOI för A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.
- Ladda ner fulltext (pdf) av A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.
Adverse childhood experiences and resilience among adult women: A population-based study

Danielsdottir, Hilda Bjork; Aspelund, Thor; Thordardottir, Edda Bjork; Fall, Katja et al.

Ingår i eLIFE, 2022
- DOI för Adverse childhood experiences and resilience among adult women: A population-based study
Ambient air pollution and inflammation-related proteins during early childhood

He, Shizhen; Klevebro, Susanna; Baldanzi, Gabriel; Pershagen, Goran et al.

Ingår i Environmental Research, 2022
- DOI för Ambient air pollution and inflammation-related proteins during early childhood
- Ladda ner fulltext (pdf) av Ambient air pollution and inflammation-related proteins during early childhood
An online atlas of human plasma metabolite signatures of gut microbiome composition

Dekkers, Koen; Sayols-Baixeras, Sergi; Baldanzi, Gabriel; Nowak, Christoph et al.

Ingår i Nature Communications, 2022
- DOI för An online atlas of human plasma metabolite signatures of gut microbiome composition
- Ladda ner fulltext (pdf) av An online atlas of human plasma metabolite signatures of gut microbiome composition
App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden

Kennedy, Beatrice; Fitipaldi, Hugo; Hammar, Ulf; Maziarz, Marlena et al.

Ingår i Nature Communications, 2022
- DOI för App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden
- Ladda ner fulltext (pdf) av App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden
Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort

Bianchi, Matteo; Kozyrev, Sergey V.; Notarnicola, Antonella; Hultin-Rosenberg, Lina et al.

Ingår i Arthritis & Rheumatology, s. 342-352, 2022
- DOI för Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort
- Ladda ner fulltext (pdf) av Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort
Development of gut microbiota during the first 2 years of life

Wernroth, Lisa; Peura, Sari; Hedman, Anna M.; Hetty, Susanne et al.

Ingår i Scientific Reports, 2022
- DOI för Development of gut microbiota during the first 2 years of life
- Ladda ner fulltext (pdf) av Development of gut microbiota during the first 2 years of life
Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Pellegrinelli, V; Rodriguez-Cuenca, S.; Rouault, C.; Figueroa-Juarez, E. et al.

Ingår i Nature Metabolism, s. 476-+, 2022
- DOI för Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance
Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study

Ahmad, Shafqat; Hammar, Ulf; Kennedy, Beatrice; Salihovic, Samira et al.

Ingår i Diabetes, s. 329-339, 2022
- DOI för Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study
- Ladda ner fulltext (pdf) av Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study
Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study

Baldanzi, Gabriel; Hammar, Ulf; Fall, Tove; Lindberg, Eva et al.

Ingår i Sleep, 2022
- DOI för Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study
- Ladda ner fulltext (pdf) av Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study
Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction: A Mendelian Randomization Study

Rukh, Gull; Ahmad, Shafqat; Lind, Lars; Schioth, Helgi Birgir

Ingår i Frontiers in Genetics, 2022
- DOI för Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction: A Mendelian Randomization Study
- Ladda ner fulltext (pdf) av Evidence of a Causal Link Between the Well-Being Spectrum and the Risk of Myocardial Infarction: A Mendelian Randomization Study
Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of US adults

Holliday, Katelyn M.; Gondalia, Rahul; Baldassari, Antoine; Justice, Anne E. et al.

Ingår i Environmental Research, 2022
- DOI för Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of US adults
Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study

Ahmad, Shafqat; Arnlov, Johan; Larsson, Susanna C.

Ingår i Nutrients, s. 509, 2022
- DOI för Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study
- Ladda ner fulltext (pdf) av Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study
Genetics of liver fat and volume associate with altered metabolism and whole body magnetic resonance imaging

Ahmad, Shafqat; Carrasquilla, Germán; Langner, Taro; Menzel, Uwe et al.

Ingår i Journal of Hepatology, 2022
- DOI för Genetics of liver fat and volume associate with altered metabolism and whole body magnetic resonance imaging