Molecular Epidemiology
![Members of the research group are jumping in front of a brick wall.](/images/200.d7e038f18f0f9df5915862/1714036735961/Gruppbild_hopparHZ4A8271_foto%20Danish%20Saroee_1932x828.jpg)
Our research focuses on the causes and consequences of diabetes and cardiovascular diseases, the identification of predictive biomarkers and lifestyle factors, and novel methods in disease surveillance.
We apply traditional and modern methods for causal inference in large observational datasets, some of which our team have developed based on high-throughput molecular methods. These data include metabolomics, metagenomics, genomics, proteomics, and imiomics. We have also performed large register linkages and collected COVID-19 data through an innovative national syndromic surveillance app.
We are an international, creative, and collaborative research environment with an ambition to make a positive impact on society. Our research is projected to lead to important new insights into disease mechanisms, which in turn can facilitate the development of new treatments for these diseases, as well as new biomarkers of disease for improved risk prediction and prognostics. Additionally, in response to the COVID-19 pandemic, the group has been striving to develop novel methods for monitoring the transmission of infectious disease agents and for establishing a systematic approach to vaccination safety to safeguard communities in future health crises.
Publications
Part of EBioMedicine, 2024
- DOI for Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS
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Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
Part of Scientific Reports, p. 8933, 2024
Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study.
Part of GeroScience, 2024
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Part of Nature, p. 347-357, 2024
- DOI for Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
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Part of Diabetologia, 2024
Markers of imminent myocardial infarction
Part of Nature Cardiovascular Research, 2024
- DOI for Markers of imminent myocardial infarction
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Mediterranean Diet Adherence and Risk of All-Cause Mortality in Women
Part of JAMA Network Open, 2024
- DOI for Mediterranean Diet Adherence and Risk of All-Cause Mortality in Women
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Multi-modal single cell sequencing of B cells in primary Sjögren's Syndrome.
Part of Arthritis & Rheumatology, p. 255-267, 2024
- DOI for Multi-modal single cell sequencing of B cells in primary Sjögren's Syndrome.
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Part of Spatial and Spatio-temporal Epidemiology, 2024
- DOI for Predicting COVID-19 hospitalizations: The importance of healthcare hotlines, test positivity rates and vaccination coverage
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Part of Eur J Epidemiol, 2024
Part of Circulation, 2024
Part of European Journal of Public Health, p. 14-21, 2024
- DOI for Sociodemographic characteristics and COVID-19 testing rates: spatiotemporal patterns and impact of test accessibility in Sweden
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Part of G3, 2024
A machine learning based approach to identify carotid subclinical atherosclerosis endotypes
Part of Cardiovascular Research, p. 2594-2606, 2023
Part of PLOS ONE, 2023
- DOI for Adipokines and risk of rheumatoid arthritis: A two-sample multivariable Mendelian randomisation study
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Part of BMJ Open, 2023
- DOI for Association between obstructive sleep apnoea and cancer: a cross-sectional, population-based study of the DISCOVERY cohort
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Part of Revista Española de Cardiología, p. 86-93, 2023
Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
Part of ERJ Open Research, 2023
- DOI for Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
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Part of CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2023
Part of Journal of the American College of Cardiology, p. 1343-1359, 2023
Diminishing benefits of urban living for children and adolescents' growth and development
Part of Nature, p. 874-883, 2023
- DOI for Diminishing benefits of urban living for children and adolescents' growth and development
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Part of Nature Human Behaviour, 2023
- DOI for Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women
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Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study
Part of American Society of Nephrology. Clinical Journal, p. 17-27, 2023
- DOI for Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases A Mendelian Randomization Study
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Part of Nature Genetics, p. 973-983, 2023
Guidelines for microbiome studies in renal physiology
Part of American Journal of Physiology - Renal Physiology, 2023
Part of Nature Genetics, p. 1448-+, 2023
- DOI for GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
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Part of Nature Communications, 2023
- DOI for Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study.
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Large-Scale Metabolomics and the Incidence of Cardiovascular Disease
Part of Journal of the American Heart Association, 2023
- DOI for Large-Scale Metabolomics and the Incidence of Cardiovascular Disease
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Loci for insulin processing and secretion provide insight into type 2 diabetes risk.
Part of American Journal of Human Genetics, p. 284-299, 2023
Part of Chest, p. 503-516, 2023
- DOI for OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
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Part of Environment International, 2023
- DOI for Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
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Part of Cardiovascular Diabetology, 2023
- DOI for Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study
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Prevalence of Charcot Foot in Subjects With Diabetes: A Nationwide Cohort Study
Part of Diabetes Care, 2023
Part of European Journal of Public Health, 2023
Part of Circulation, p. 459-472, 2023
- DOI for Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
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Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
Part of American Journal of Preventive Medicine, p. 60-66, 2023
- DOI for Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
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Part of Diabetologia, p. 174-189, 2023
The metabolic profile of waist to hip ratio-A multi-cohort study
Part of PLOS ONE, 2023
- DOI for The metabolic profile of waist to hip ratio-A multi-cohort study
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Part of Scientific Reports, 2022
- DOI for A genome-wide association study in a large community-based cohort identifies multiple loci associated with susceptibility to bacterial and viral infections
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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Part of American Journal of Human Genetics, p. 1366-1387, 2022
Part of European Journal of Public Health, p. 799-806, 2022
- DOI for A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19.
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Adverse childhood experiences and resilience among adult women: A population-based study
Part of eLIFE, 2022
Ambient air pollution and inflammation-related proteins during early childhood
Part of Environmental Research, 2022
- DOI for Ambient air pollution and inflammation-related proteins during early childhood
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An online atlas of human plasma metabolite signatures of gut microbiome composition
Part of Nature Communications, 2022
- DOI for An online atlas of human plasma metabolite signatures of gut microbiome composition
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Part of Nature Communications, 2022
- DOI for App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden
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Part of Arthritis & Rheumatology, p. 342-352, 2022
- DOI for Contribution of rare genetic variation to disease susceptibility in a large Scandinavian myositis cohort
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Development of gut microbiota during the first 2 years of life
Part of Scientific Reports, 2022
- DOI for Development of gut microbiota during the first 2 years of life
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Part of Nature Metabolism, p. 476-+, 2022
Part of Diabetes, p. 329-339, 2022
- DOI for Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study
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Part of Sleep, 2022
- DOI for Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study
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