Cancer Pharmacology and Computational Medicine

Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening

Gezelius, Henrik; Enblad, Anna Pia; Lundmark, Anders; Åberg, Martin et al.

Part of NAR Genomics and Bioinformatics, 2024

• DOI for Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
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Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain

Gupta, Rajesh Kumar; Niklasson, Mia; Bergström, Tobias; Segerman, Anna et al.

Part of Scientific Reports, 2024

• DOI for Tumor-specific migration routes of xenotransplanted human glioblastoma cells in mouse brain
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Pharmacokinetics and Metabolism of Melflufen, an Alkylating Peptide-Drug Conjugate, in Patients with Relapsed Refractory Multiple Myeloma

Huledal, Gunilla; Ruiz-Garcia, Ana; Kawakatsu, Sonoko; Wang, Xiaoning et al.

Part of Journal of clinical pharmacology, p. 240-252, 2024

• DOI for Pharmacokinetics and Metabolism of Melflufen, an Alkylating Peptide-Drug Conjugate, in Patients with Relapsed Refractory Multiple Myeloma

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Part of BMC Pharmacology & Toxicology, 2024

• DOI for Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
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Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Andersson, Claes; Ye, Jiawei; Blom, Kristin; Fryknäs, Mårten et al.

Part of Anti-Cancer Drugs, p. 92-102, 2023

• DOI for Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients
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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Part of Scientific Reports, 2023

• DOI for Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
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The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Dijkstra, E. A.; Zwart, W. H.; Nilsson, P. J.; Putter, H. et al.

Part of ESMO Open, 2023

• DOI for The value of post-operative chemotherapy after chemoradiotherapy in patients with high-risk locally advanced rectal cancerdresults from the RAPIDO trial

Somatic Exonic Deletions in RUNX1 Constitutes a Novel Recurrent Genomic Abnormality in Acute Myeloid Leukemia

Eriksson, Anna; Engvall, Marie; Mathot, Lucy; Österroos, Albin et al.

Part of Clinical Cancer Research, p. 2826-2834, 2023

• DOI for Somatic Exonic Deletions in RUNX1 Constitutes a Novel Recurrent Genomic Abnormality in Acute Myeloid Leukemia

Disease phenotype prediction in multiple sclerosis

Herman, Stephanie; Arvidsson McShane, Staffan; Zhukovsky, Christina; Emami, Payam et al.

Part of iScience, 2023

• DOI for Disease phenotype prediction in multiple sclerosis
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Aminopeptidases in Cancer, Biology and Prospects for Pharmacological Intervention

Holstein, Sarah A.; Heckman, Caroline A.; Davies, Faith E.; Morgan, Gareth J. et al.

Part of Current Cancer Drug Targets, p. 25-46, 2023

• DOI for Aminopeptidases in Cancer, Biology and Prospects for Pharmacological Intervention

Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Karlsson, Jesper; Wettero, Jonas; Potempa, Lawrence A.; Fernandez-Botran, Rafael et al.

Part of Journal of Autoimmunity, 2023

• DOI for Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP
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Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial

Lyytinen, Gustaf; Brynedal, Amelie; Anesater, Erik; Antoniewicz, Lukasz et al.

Part of Cardiovascular Toxicology, p. 255-264, 2023

• DOI for Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial
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Evaluation of domestic animal sperm head morphology via flow cytometric DNA labelling and pulse shape analysis using bull and stallion spermatozoa as model species

Nagy, Szabolcs; Kovacs, Barnabas; Johannisson, Anders

Part of Reproduction in domestic animals, p. 1569-1575, 2023

• DOI for Evaluation of domestic animal sperm head morphology via flow cytometric DNA labelling and pulse shape analysis using bull and stallion spermatozoa as model species
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Managing leukemia patients via liquid biopsy and super rolling circle amplification (superRCA)

Robelius, Anna; Chen, Lei; Amini, Rose-Marie; Cavelier, Lucia et al.

Part of Journal of Internal Medicine, p. 228-237, 2023

• DOI for Managing leukemia patients via liquid biopsy and super rolling circle amplification (superRCA)

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients

Sarén, Tina; Ramachandran, Mohanraj; Gammelgård, Gustav; Lövgren, Tanja et al.

Part of Clinical Cancer Research, p. 4139-4152, 2023

• DOI for Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
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Preclinical tumor-immune modeling: For the identification of immunomodulatory drugs

Selvin, Tove

2023

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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Part of BMC Cancer, 2023

• DOI for Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
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Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome

Bjersand, Kathrine; Blom, Kristin; Sundström Poromaa, Inger; Stålberg, Karin et al.

Part of International Journal of Oncology, 2022

• DOI for Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Part of NATURE CANCER, p. 156, 2022

• DOI for Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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Quiescent cancer cells: Three-dimensional cell models for evaluation of new therapeutics

Ek, Frida

2022

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Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue

Gholiha, Alex R.; Hollander, Peter; Löf, Liza; Larsson, Anders et al.

Part of Cancers, 2022

• DOI for Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue
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Lysophophatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3

Jacquot, F.; Khoury, S.; Labrum, B.; Delanoe, K. et al.

Part of Pain, p. 1999-2013, 2022

• DOI for Lysophophatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3
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Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Karlsson, Henning; Fryknäs, Mårten; Senkowski, Wojciech; Larsson, Rolf et al.

Part of Oncology Letters, 2022

• DOI for Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
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Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study

Lindskog, Magnus; Laurell, Anna; Kjellman, Anders; Melichar, Bohuslav et al.

Part of European Urology Open Science, p. 38-45, 2022

• DOI for Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study
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Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Part of Nature Communications, 2022

• DOI for Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
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Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Part of Scientific Reports, 2022

• DOI for Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
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Surgical waiting times and all-cause mortality in patients with non-metastatic renal cell carcinoma

Rosenblad, Andreas; Sundqvist, Pernilla; Harmenberg, Ulrika; Hellström, Mikael et al.

Part of Scandinavian journal of urology, p. 383-390, 2022

• DOI for Surgical waiting times and all-cause mortality in patients with non-metastatic renal cell carcinoma
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Plasma protein biomarker profiling reveals major differences between acute leukaemia, lymphoma patients and controls

Sabaa, Amal Abu; Shen, Qiujin; Lennmyr, Emma; Enblad, Anna Pia et al.

Part of New Biotechnology, p. 21-29, 2022

• DOI for Plasma protein biomarker profiling reveals major differences between acute leukaemia, lymphoma patients and controls
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Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Selvin, Tove; Fasterius, Erik; Jarvius, Malin; Fryknäs, Mårten et al.

Part of Scientific Reports, 2022

• DOI for Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
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Metabolomics: The Stethoscope for the Twenty-First Century

Ashrafian, Hutan; Sounderajah, Viknesh; Glen, Robert; Ebbels, Timothy et al.

Part of Medical principles and practice, p. 301-310, 2021

• DOI for Metabolomics: The Stethoscope for the Twenty-First Century
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Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

Bergström, Sofia; Remnestål, Julia; Yousef, Jamil; Olofsson, Jennie et al.

Part of Annals of Clinical and Translational Neurology, p. 1456-1470, 2021

• DOI for Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease
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Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid

Boström, Gustaf; Freyhult, Eva; Virhammar, Johan; Alcolea, Daniel et al.

Part of Journal of Alzheimer's Disease, p. 629-640, 2021

• DOI for Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Byrgazov, Konstantin; Lind, Thomas; Rasmusson, Annica J.; Andersson, Claes et al.

Part of Bone Reports, 2021

• DOI for Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

Bülow Anderberg, Sara; Luther, Tomas; Berglund, Malin; Larsson, Rolf et al.

Part of Cytokine, 2021

• DOI for Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients
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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Handin, Niklas; Mickols, Evgeniya; Ölander, Magnus; Rudfeldt, Jakob et al.

Part of iScience, 2021

• DOI for Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
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DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)

Krali, Olga; Palle, J; Bäcklin, Christofer; Abrahamsson, Jonas et al.

Part of Genes, 2021

• DOI for DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
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A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

Mansoori, Sharmineh; Fryknäs, Mårten; Alvfors, Carina; Loskog, Angelica et al.

Part of Scientific Reports, 2021

• DOI for A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
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Challenging conventional karyotyping by next-generation karyotyping in 281 intensively treated patients with AML

Mareschal, Sylvain; Palau, Anna; Lindberg, Johan; Ruminy, Philippe et al.

Part of Blood Advances, p. 1003-1016, 2021

• DOI for Challenging conventional karyotyping by next-generation karyotyping in 281 intensively treated patients with AML

Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma

Mörth, Charlott; Sabaa, Amal Abu; Freyhult, Eva; Christersson, Christina et al.

Part of Cardio-Oncology, 2021

• DOI for Plasma proteome profiling of cardiotoxicity in patients with diffuse large B-cell lymphoma
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Metabolic drift in the aging nervous system is reflected in human cerebrospinal fluid

Peters, Kristian; Herman, Stephanie; Emami Khoonsari, Payam; Burman, Joachim et al.

Part of Scientific Reports, 2021

• DOI for Metabolic drift in the aging nervous system is reflected in human cerebrospinal fluid
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Toll-like receptor 4 methylation grade is linked to depressive symptom severity

Rasmusson, Annica J.; Gallwitz, Maike; Soltanabadi, Bardia; Ciuculete, Diana-Maria et al.

Part of Translational Psychiatry, 2021

• DOI for Toll-like receptor 4 methylation grade is linked to depressive symptom severity
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Approaches for containerized scientific workflows in cloud environments with applications in life science

Spjuth, Ola; Capuccini, Marco; Carone, Matteo; Larsson, Anders et al.

Part of F1000 Research, p. 513-513, 2021

• DOI for Approaches for containerized scientific workflows in cloud environments with applications in life science

COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial

Welen, Karin; Overby, Anna K.; Ahlm, Clas; Freyhult, Eva et al.

Part of Trials, 2021

• DOI for COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial
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Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Part of Scientific Reports, 2020

• DOI for Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
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Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide

Byrgazov, Konstantin; Andersson, Claes; Salzer, Benjamin; Bozsaky, Eva et al.

Part of THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2020

• DOI for Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
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Algorithmic discovery, development and personalized selection of higher-order drug cocktails: A label-free live-cell imaging & secretomics approach

Chantzi, Efthymia

2020

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COMBSecretomics: a pragmatic methodological framework for higher-order drug combination analysis using secretomics

Chantzi, Efthymia; Neidlin, Michael; Macheras, George A.; Alexopoulos, Leonidas G. et al.

Part of PLOS ONE, 2020

• DOI for COMBSecretomics: a pragmatic methodological framework for higher-order drug combination analysis using secretomics
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Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.

Hartmann, Rafael; Fahrner, Raphael; Shevshenko, Denys; Fryknäs, Mårten et al.

Part of ChemMedChem, p. 2500-2512, 2020

• DOI for Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.
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Gene Expression Alterations during Development of Castration-Resistant Prostate Cancer Are Detected in Circulating Tumor Cells

Josefsson, Andreas; Larsson, Karin; Freyhult, Eva; Damber, Jan-Erik et al.

Part of Cancers, 2020

• DOI for Gene Expression Alterations during Development of Castration-Resistant Prostate Cancer Are Detected in Circulating Tumor Cells
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Genomic and transcriptomic features of dermatofibrosarcoma protuberans: Unusual chromosomal origin of the COL1A1-PDGFB fusion gene and synergistic effects of amplified regions in tumor development

Koster, Jan; Arbajian, Elsa; Viklund, Björn; Isaksson, Anders et al.

Part of Cancer Genetics, p. 34-41, 2020

• DOI for Genomic and transcriptomic features of dermatofibrosarcoma protuberans: Unusual chromosomal origin of the COL1A1-PDGFB fusion gene and synergistic effects of amplified regions in tumor development
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