Clinical Physiology
![A woman is looking at two computer screens from a MRI scan.](/images/200.d7e038f18f0f9df59160d5/1714045331352/_X9A9023_1932x828.jpg)
Clinical physiology involves functional investigations of different organs such as the heart, the blood vessels, the lungs and the gastrointestinal tract. The focus of our research is the development of high precision methods for fast and accurate diagnosis of various illnesses, and is most advanced within the fields of cardiovascular disease, lung function tests and investigations of the gastrointestinal tract.
Cardiovascular research
The research covers foremost ultrasound investigations of the heart and the blood vessels, including development of image analysis and software for calculation of various physiological parameters for diagnosis and prognosis of different cardiovascular diseases. Among several achievements have variables of pressure, flow and acceleration times been correlated to measurements by cardiac catheterization. This has allowed earlier and non-invasive diagnosis of different types of lesions within the cardiovascular system.
Lung function research
Studies are conducted for the development of new investigational methods such as impulse oscillometry, whereby a sonic wave is sent into the lungs. This non-invasive method to measure respiratory mechanics causes much less discomfort than ordinary, common practice, lung function tests. We also perform studies of diseases that affect lungs and airways to detect initial signs of disease and thereby start early treatment. These studies include diseases such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, alveolitis and other inflammatory lung diseases. The lung function research includes also lung changes in connection to anesthesia and breathing dysfunction.
Studies on the gastrointestinal tract
The research includes pressure and flow measurements within the upper and lower gastrointestinal tract as well as analyses of gases that may trace inflammation in the gastrointestinal tract. Studies are conducted using a small video camera, enclosed in a 2,5 cm capsule that is swallowed, and image analysis are employed to identify inflammation and other lesions in the small intestine.
Studies of diseases by integrated physiological tests
Through ergospirometry (measurement of respiration and gas metabolism during ergometer exercise) one can study changes from both the respiratory system and the cardiovascular system, as well as muscular function in patients with multiple organ dysfunctions that affect the patients work capacity. Data from these tests guide the treatment and prognosis of different diseases and is also used for risk-stratification in advance of major surgery.
Publications
Part of Respiratory Research, 2024
- DOI for Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women
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Part of Eur J Epidemiol, 2024
Urticaria and angioedema in Estonia, Iceland and Sweden.
Part of Clinical and Experimental Allergy, 2024
Device comparison study to measure nasal nitric oxide in relation to primary ciliary dyskinesia
Part of Journal of Breath Research, 2024
- DOI for Device comparison study to measure nasal nitric oxide in relation to primary ciliary dyskinesia
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Cardiopulmonary exercise testing and body composition.
Part of ERJ open research, 2024
The Impact of Airway Obstruction on Feno Values in Asthma Patients.
Part of Journal of Allergy and Clinical Immunology, p. 111-117, 2024
Continuous improvement of FEV1 in severe eosinophilic asthmatics on anti-interleukin-5 therapy.
Part of Allergy. European Journal of Allergy and Clinical Immunology, 2024
Part of BMJ open respiratory research, 2024
- DOI for Respiratory symptoms, exacerbations and sleep disturbances are more common among participants with asthma and chronic airflow limitation: an epidemiological study in Estonia, Iceland and Sweden
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Part of Respiratory Medicine, 2024
- DOI for Gastroesophageal reflux and snoring are related to asthma and respiratory symptoms: Results from a Nordic longitudinal population survey.
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Biomarkers of chronic airflow limitation and COPD identified by mass spectrometry
Part of ERJ Open Research, 2024
- DOI for Biomarkers of chronic airflow limitation and COPD identified by mass spectrometry
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Factors most strongly associated with breathlessness in a population aged 50-64 years
Part of ERJ Open Research, 2024
- DOI for Factors most strongly associated with breathlessness in a population aged 50-64 years
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Part of Respiratory Medicine, 2024
- DOI for Inhomogeneity of ventilation in smokers and mild COPD assessed by the ratio of alveolar volume to total lung capacity
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LAMA improve tissue oxygenation more than LABA in patients with COPD.
Part of Journal of applied physiology, 2024
Part of Nitric oxide, p. 60-66, 2024
Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 2959-2968, 2023
- DOI for Circulating mast cell progenitors increase in frequency during natural birch pollen exposure in allergic asthma patients
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Part of Environmental Science and Technology, p. 11750-11766, 2023
- DOI for Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants
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The role of imaging in the selection of patients for HFpEF therapy
Part of European Heart Journal Cardiovascular Imaging, p. 1343-1351, 2023
- DOI for The role of imaging in the selection of patients for HFpEF therapy
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Part of Clinical and Translational Allergy, 2023
- DOI for Allergic sensitisation and type-2 inflammation is associated with new-onset and persistent allergic disease
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Part of Respiratory Research, 2023
- DOI for Can we predict who will benefit most from biologics in severe asthma?: A post-hoc analysis of two phase 3 trials
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Part of Vascular Medicine, p. 274-281, 2023
- DOI for Nondipping blood pressure pattern predicts cardiovascular events and mortality in patients with atherosclerotic peripheral vascular disease
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Part of HEART RHYTHM O2, p. 200-206, 2023
- DOI for Prognostic value of early sustained ventricular arrhythmias in ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: A substudy of VALIDATE-SWEDEHEART trial
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Part of REVISTA ESPANOLA DE ANESTESIOLOGIA Y REANIMACION, p. 209-217, 2023
Reference equations for breathlessness during incremental cycle exercise testing
Part of ERJ Open Research, 2023
- DOI for Reference equations for breathlessness during incremental cycle exercise testing
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Part of Scandinavian Journal of Medicine and Science in Sports, p. 1509-1518, 2023
- DOI for A longitudinal study of exercise-induced bronchoconstriction and laryngeal obstruction in high school athletes
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Part of European Heart Journal Cardiovascular Imaging, 2023
New Echocardiographic Reference Values: Why They Are Welcome
Part of JACC Cardiovascular Imaging, p. 1532-1535, 2023
Part of European Respiratory Journal, 2023
- DOI for Reply: Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery
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Part of JACC Cardiovascular Imaging, p. 1193-1204, 2023
Part of European Respiratory Journal, 2023
Part of Journal of Translational Medicine, 2023
- DOI for Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort
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Part of eClinicalMedicine, 2023
- DOI for Early life exposures contributing to accelerated lung function decline in adulthood: a follow-up study of 11,000 adults from the general population
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Part of Respiratory Medicine, 2023
- DOI for Association between abdominal and general obesity and respiratory symptoms, asthma and COPD: Results from the RHINE study
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Part of ERJ Open Research, 2023
- DOI for Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters
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Part of Journal of Clinical Medicine, 2023
- DOI for Clustering Analysis Identified Three Long COVID Phenotypes and Their Association with General Health Status and Working Ability
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Inflammatory bowel disease and asthma: Results from the RHINE study
Part of Respiratory Medicine, 2023
- DOI for Inflammatory bowel disease and asthma: Results from the RHINE study
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Fathers' preconception smoking and offspring DNA methylation
Part of Clinical Epigenetics, 2023
- DOI for Fathers' preconception smoking and offspring DNA methylation
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Part of Structural Equation Modeling, p. 214-221, 2023
- DOI for A Faster Procedure for Estimating SEMs Applying Minimum Distance Estimators With a Fixed Weight Matrix
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Virtual clinic for young people with type 1 diabetes: a randomised wait-list controlled study
Part of BMC Endocrine Disorders, 2023
- DOI for Virtual clinic for young people with type 1 diabetes: a randomised wait-list controlled study
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Clinical potential of eosinophil-derived neurotoxin in asthma management
Part of Journal of Allergy and Clinical Immunology, p. 750-761, 2023
- DOI for Clinical potential of eosinophil-derived neurotoxin in asthma management
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Consequences of Using Post- or Prebronchodilator Reference Values in Interpreting Spirometry
Part of American Journal of Respiratory and Critical Care Medicine, p. 461-471, 2023
Reference values of serum total IgE in Uppsala: comparison over four decades
Part of Upsala Journal of Medical Sciences, 2023
- DOI for Reference values of serum total IgE in Uppsala: comparison over four decades
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Part of Frontiers in Cardiovascular Medicine, 2023
- DOI for Triglyceride-glucose (TyG) index is a predictor of arterial stiffness, incidence of diabetes, cardiovascular disease, and all-cause and cardiovascular mortality: A longitudinal two-cohort analysis
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Part of PLOS ONE, 2023
- DOI for Factors important for health-related quality of life in men and women: The population based SCAPIS study
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High prevalence of interstitial lung abnormalities in middle-aged never-smokers
Part of ERJ Open Research, 2023
- DOI for High prevalence of interstitial lung abnormalities in middle-aged never-smokers
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Part of ERJ Open Research, 2023
- DOI for Impulse oscillometry indices in relation to respiratory symptoms and spirometry in the Swedish Cardiopulmonary Bioimage Study
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Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
Part of ERJ Open Research, 2023
- DOI for Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
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Periodontitis is associated with airflow obstruction in the Malmö Offspring Dental Study.
Part of Journal of Clinical Periodontology, 2023
Part of Circulation, p. 459-472, 2023
- DOI for Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort
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Part of Clinical Proteomics, 2023
- DOI for Are the results from a multiplex proteomic assay and a conventional immunoassay for NT-proBNP and GDF-15 comparable?
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Part of Journal of Nuclear Medicine, p. 645-651, 2023