Clinical Neurophysiology
![Six test tubes with different coloured corks in a test tube rack.](/images/200.7630b4f918f153429f714225/1714331940896/_MG_7007_1932x828.jpg)
The research in the clinical neurophysiology unit is translational and focuses on optimizing neurophysiological parameters for diagnosis and follow-up of diseases of the peripheral and central nervous system. We have a preclinical lab with a method for measuring detailed extracellular signals from muscle and nerve cells to better map disease mechanisms.
Description of our research
Some examples of ongoing projects are biomarker development in myasthenia gravis (MG), muscle ultrasound in myopathies and analysis of the mechanisms that result in disturbed neuromuscular and neuronal signaling in autoimmune diseases such as MG. The research group also includes a number of clinical doctors and researchers who work with various projects in method development for diagnostics and follow-up. These projects aim, among other things, to improve the location of epileptic foci and to develop new methods in intraoperative monitoring and during intensive care.
Publications
Part of European Journal of Neurology, 2024
- DOI for Pregnancy outcomes for women with myasthenia gravis and their newborns: A nationwide register-based cohort study
- Download full text (pdf) of Pregnancy outcomes for women with myasthenia gravis and their newborns: A nationwide register-based cohort study
Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
Part of Clinical Neurophysiology Practice, p. 169-173, 2023
- DOI for Keeping up appearances: Don't frown upon the effects of botulinum toxin injections in facial muscles
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Part of Acta Neurologica Scandinavica, 2023
- DOI for Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
- Download full text (pdf) of Antibody-Positive Autoimmune Encephalitis and Paraneoplastic Neurological Syndrome: Epidemiology and Outcome of Neuronal Antibody Testing in Sweden
Part of European Journal of Neurology, p. 266-282, 2023
- DOI for Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
- Download full text (pdf) of Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal
Part of Neuromuscular Disorders, p. 334-338, 2023
- DOI for Implementation of tailored exercise programs for MG patients in a gym setting: a pragmatic feasibility case study
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Part of JAMA Neurology, p. 1105-1112, 2022
Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Part of Journal of Neuroimmunology, 2022
- DOI for Enrichment of serum IgG4 in MuSK myasthenia gravis patients
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Part of Advanced Functional Materials, 2022
Epidemiology, diagnostics, and biomarkers of autoimmune neuromuscular junction disorders
Part of Lancet Neurology, p. 176-188, 2022
Part of Cells, 2022
- DOI for Towards Personalized Medicine in Myasthenia Gravis: Role of Circulating microRNAs miR-30e-5p, miR-150-5p and miR-21-5p
- Download full text (pdf) of Towards Personalized Medicine in Myasthenia Gravis: Role of Circulating microRNAs miR-30e-5p, miR-150-5p and miR-21-5p
Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
Part of Neuromuscular Disorders, p. 80-83, 2022
- DOI for Novel pathogenic ALG2 mutation causing congenital myasthenic syndrome: A case report
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Part of European Journal of Neurology, p. 1706-1715, 2021
- DOI for Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
- Download full text (pdf) of Cancer in myasthenia gravis subtypes in relation to immunosuppressive treatment and acetylcholine receptor antibodies: A Swedish nationwide register study
Part of Clinical Neurophysiology, p. 1733-1740, 2021
- DOI for Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study
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Epidemiology of Myasthenia Gravis in Sweden 2006-2016
Part of Brain and Behavior, 2020
- DOI for Epidemiology of Myasthenia Gravis in Sweden 2006-2016
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Part of Clinical Neurophysiology Practice, p. 46-49, 2020
- DOI for Botulinum toxin injections associated with suspected myasthenia gravis: An underappreciated cause of MG-like clinical presentation
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Mortality rates and causes of death in Swedish Myasthenia Gravis patients
Part of Neuromuscular Disorders, p. 815-824, 2020
- DOI for Mortality rates and causes of death in Swedish Myasthenia Gravis patients
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Myasthenia gravis patient and physician opinions about immunosuppressant reduction
Part of Muscle and Nerve, p. 767-772, 2020
Myasthenia Gravis and Physical Exercise: A Novel Paradigm
Part of Frontiers in Neurology, 2020
- DOI for Myasthenia Gravis and Physical Exercise: A Novel Paradigm
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Part of Frontiers in Immunology, 2020
- DOI for Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs
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Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
Part of Frontiers in Immunology, 2020
- DOI for Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
- Download full text (pdf) of Circulating miRNAs as Potential Biomarkers in Myasthenia Gravis: Tools for Personalized Medicine
miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27
Part of Neuroscience research, p. 46-52, 2020
Pattern of Habitual Physical Exercise in Myasthenia Gravis Patients
Part of JOURNAL OF NEUROMUSCULAR DISEASES, p. 85-91, 2019
Part of BMJ Open, 2019
- DOI for Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
- Download full text (pdf) of Study protocol for a randomised controlled trial with clinical, neurophysiological, laboratory and radiological outcome for surgical versus non-surgical treatment for lumbar spinal stenosis: the Uppsala Spinal Stenosis Trial (UppSten)
Cognitive dysfunction in mice with passively induced MuSK antibody seropositive myasthenia gravis
Part of Journal of the Neurological Sciences, p. 15-21, 2019
Facing the challenges of electrodiagnostic studies in the very elderly (>80 years) population
Part of Clinical Neurophysiology, p. 1091-1097, 2019
miR-30e-5p as predictor of generalization in ocular myasthenia gravis
Part of Annals of clinical and translational neurology, p. 243-251, 2019
- DOI for miR-30e-5p as predictor of generalization in ocular myasthenia gravis
- Download full text (pdf) of miR-30e-5p as predictor of generalization in ocular myasthenia gravis
Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
Part of Scientific Reports, 2019
- DOI for Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum
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Circulating microRNA plasma profile in MuSK plus myasthenia gravis
Part of Journal of Neuroimmunology, p. 87-91, 2018
Advances in autoimmune myasthenia gravis management
Part of Expert Review of Neurotherapeutics, p. 573-588, 2018
Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
Part of Frontiers in Physiology, 2018
- DOI for Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
- Download full text (pdf) of Long-Term High-Density Extracellular Recordings Enable Studies of Muscle Cell Physiology
Part of Journal of Neuroimmunology, p. 164-170, 2018
- DOI for Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis
- Download full text (pdf) of Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis
Lifestyle factors and disease-specific differences in subgroups of Swedish Myasthenia Gravis
Part of Acta Neurologica Scandinavica, p. 557-565, 2018
Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
Part of Neurology, 2018
- DOI for Thymectomy lowers the myasthenia gravis biomarker miR-150-5p
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Part of Medicine, 2018
- DOI for The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study
- Download full text (pdf) of The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study
Circulating microRNAs as potential biomarkers in myasthenia gravis patients.
Part of Annals of the New York Academy of Sciences, p. 33-40, 2018
High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
Part of Clinical Neurophysiology Practice, p. 163-169, 2017
- DOI for High-resistance strength training does not affect nerve cross sectional area – An ultrasound study
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Part of Journal of clinical neurophysiology, p. 400-407, 2017
Part of Toxins, 2017
- DOI for Neurophysiological Measures of Efficacy and Safety for Botulinum Toxin Injection in Facial and Bulbar Muscles: Special Considerations
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Part of Brain and Behavior, 2017
- DOI for Diversity in mental fatigue and social profile of patients with myasthenia gravis in two different Northern European countries
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Part of Muscle and Nerve, p. 207-214, 2017
Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
Part of Scientific Reports, 2017
- DOI for Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
- Download full text (pdf) of Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients.
Part of Clinical Neurophysiology, p. 3480-3484, 2016
Part of Dermatologic Surgery, p. 967-976, 2016
Compound Motor Action Potential: Electrophysiological Marker for Muscle Training
Part of Journal of clinical neurophysiology, p. 340-345, 2016
Part of Acta Neurologica Belgica, p. 57-63, 2016
Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
Part of Journal of Neuroimmunology, p. 21-26, 2016
- DOI for Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
- Download full text (pdf) of Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis.
Part of Acta Dermato-Venereologica, p. 948-951, 2015
- DOI for Regional Diffusion of Botulinum Toxin in Facial Muscles: A Randomised Double-blind Study and a Consideration for Clinical Studies with Split-face Design
- Download full text (pdf) of Regional Diffusion of Botulinum Toxin in Facial Muscles: A Randomised Double-blind Study and a Consideration for Clinical Studies with Split-face Design
Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients
Part of Journal of the Neurological Sciences, p. 90-96, 2015
- DOI for Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients
- Download full text (pdf) of Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients
Guidelines for pre-clinical animal and cellular models of MuSK-myasthenia gravis
Part of Experimental Neurology, p. 29-40, 2015
How clinical trials of myasthenia gravis can inform pre-clinical drug development
Part of Experimental Neurology, p. 78-81, 2015