Haematology
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The research group conducts clinical research in various forms of leukaemias and myeloproliferative diseases, but also in anaemia treatment and nursing. Through preclinical drug development, participation in a large number of clinical trials and studies based on our population-based cancer registries, we try to develop new treatment methods and better care for affected patients.
Haematology includes both benign and malignant diseases. Among the benign are different forms of cytopenias, both hereditary and aquired, such as anaemias, neutropenias and thrombocytopenias, as well as iron metabolism disorders. The malignant haematologic diseases constitute a heterogeneous group of cancer diseases which are usually caused by uncontrolled growth of blood cells.
In most cases it is immature stem cells that have lost their growth regulation and/or their ability to differentiate into mature effector cells of either the myeloid or the lymphoid lineages. Such loss of control may give rise to both acute and chronic leukemias with overproduction of white blood cells but also to myeloproliferativa neoplasms with over-production of red cells and/or platelets.
Focus of research
The research is conducted by a number of teams, being formed from the knowledge basis of the most important disease fields in haematology.Currently we focus on the following areas:
- Development and testing of new drugs and therapy strategies in malignant haematological diseases; acute myelogenous leukaemia, acute lymphoblastic leukemia, myelodysplastic syndrome, chronic myelogenous leukaemia, chronic lymphocytic leukemia and multiple myeloma.
- Studies bases on the Swedish national, population based quality registries formalignant haematological diseases.
- Translational research in association with the regional biobank project U-CAN.
- Studies on myeloproliferativa neoplasms, cancer anaemia and supportive care.
An important part of the activities of the Haematology group is also leadership and participation in national and international research groups for initiating international studies, and for the development of treatment guidelines and Centres of clinical excellence.
Publications
Systemic mastocytosis: dying or survivin
Part of Blood, p. 945-947, 2024
Clinical and Genetic studies in Chronic Myeloid Leukaemia
2024
Part of BMC Nursing, 2024
- DOI for Patient perceived quality of cirrhosis care – adjunctive nurse-based care versus standard medical care: a pragmatic multicentre randomised controlled study
- Download full text (pdf) of Patient perceived quality of cirrhosis care – adjunctive nurse-based care versus standard medical care: a pragmatic multicentre randomised controlled study
Part of Leukemia, p. 109-125, 2024
- DOI for Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
- Download full text (pdf) of Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation
2024
Part of European Journal of Haematology, p. 301-309, 2024
AL amyloidosis: Study of epidemiology, diagnosis and treatment with emphasis on heart involvement
2024
Part of ESC Heart Failure, p. 44-53, 2024
- DOI for Outcome prediction by myocardial external efficiency from 11C-acetate positron emission tomography in cardiac amyloidosis
- Download full text (pdf) of Outcome prediction by myocardial external efficiency from 11C-acetate positron emission tomography in cardiac amyloidosis
Part of Journal of Neurology, Neurosurgery and Psychiatry, p. 125-133, 2024
- DOI for Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
- Download full text (pdf) of Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study
Delineating functional and molecular impact of ex vivo sample handling in precision medicine
Part of npj Precision Oncology, 2024
- DOI for Delineating functional and molecular impact of ex vivo sample handling in precision medicine
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Part of Transplantation and Cellular Therapy, p. 5810-58100000000, 2023
Part of Leukemia, p. 1156-1159, 2023
- DOI for The impact of Covid-19 in patients with chronic myeloid leukemia: a nationwide population-based study
- Download full text (pdf) of The impact of Covid-19 in patients with chronic myeloid leukemia: a nationwide population-based study
Part of British Journal of Haematology, p. 353-356, 2023
Part of Blood, p. 73-89, 2023
- DOI for Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
- Download full text (pdf) of Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
Part of Acta Oncologica, p. 1723-1731, 2023
- DOI for Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia
- Download full text (pdf) of Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia
Part of Clinical Cancer Research, p. 2826-2834, 2023
Part of Frontiers in Immunology, 2023
- DOI for Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study
- Download full text (pdf) of Prevention of CMV/EBV reactivation by double-specific T cells in patients after allogeneic stem cell transplantation: results from the randomized phase I/IIa MULTIVIR-01 study
Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma
Part of Upsala Journal of Medical Sciences, 2023
- DOI for Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma
- Download full text (pdf) of Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma
Part of PLOS ONE, 2023
- DOI for Feeling safe or falling through the cracks – Patients’ experiences of healthcare in cirrhosis illness: A qualitative study
- Download full text (pdf) of Feeling safe or falling through the cracks – Patients’ experiences of healthcare in cirrhosis illness: A qualitative study
Part of Blood Advances, p. 1713-1724, 2023
Invasive fungal infection by Peziza ostracoderma in an immunocompromised patient
Part of Medical Mycology Case Reports, p. 26-30, 2023
- DOI for Invasive fungal infection by Peziza ostracoderma in an immunocompromised patient
- Download full text (pdf) of Invasive fungal infection by Peziza ostracoderma in an immunocompromised patient
Part of European Journal of Haematology, 2023
- DOI for Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.
- Download full text (pdf) of Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions.
MDS-Comorbidity Index using register data has prognostic impact in Swedish MDS patients
Part of Leukemia research, 2023
- DOI for MDS-Comorbidity Index using register data has prognostic impact in Swedish MDS patients
- Download full text (pdf) of MDS-Comorbidity Index using register data has prognostic impact in Swedish MDS patients
Chronic lymphocytic leukemia: Studies on cardiovascular disease, biomarkers and subclones
2023
Impact of daratumumab-based induction on stem cell collection parameters in Swedish myeloma patients
Part of Haematologica, p. 610-614, 2023
- DOI for Impact of daratumumab-based induction on stem cell collection parameters in Swedish myeloma patients
- Download full text (pdf) of Impact of daratumumab-based induction on stem cell collection parameters in Swedish myeloma patients
Part of Frontiers in Immunology, 2023
- DOI for Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19: An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry
- Download full text (pdf) of Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19: An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry
Part of Journal of Allergy and Clinical Immunology, p. 581-590, 2023
Part of eJHaem, p. 876-881, 2023
- DOI for Next-generation sequencing of baseline genetic mutations and outcomes of eltrombopag and azacitidine therapy in patients with myelodysplastic syndromes and thrombocytopenia: Data from the SUPPORT clinical trial
- Download full text (pdf) of Next-generation sequencing of baseline genetic mutations and outcomes of eltrombopag and azacitidine therapy in patients with myelodysplastic syndromes and thrombocytopenia: Data from the SUPPORT clinical trial
2023
Therapy-related MDS dissected based on primary disease and treatment—a nationwide perspective
Part of Leukemia, p. 1103-1112, 2023
Part of Haematologica, p. 1015-1025, 2023
- DOI for Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
- Download full text (pdf) of Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications
Part of PLOS ONE, 2023
- DOI for Population-based real-world registry study to evaluate clinical outcomes of chronic graft-versus-host disease
- Download full text (pdf) of Population-based real-world registry study to evaluate clinical outcomes of chronic graft-versus-host disease
Part of Transplantation and Cellular Therapy, 2023
Managing leukemia patients via liquid biopsy and super rolling circle amplification (superRCA)
Part of Journal of Internal Medicine, p. 228-237, 2023
Analysis of human lung mast cells by single cell RNA sequencing
Part of Frontiers in Immunology, 2023
- DOI for Analysis of human lung mast cells by single cell RNA sequencing
- Download full text (pdf) of Analysis of human lung mast cells by single cell RNA sequencing
Part of Transfusion and apheresis science, 2023
- DOI for Real-world clinical characterization, healthcare resource utilization and productivity loss in chronic graft versus host patients exposed to extracorporeal photopheresis in Sweden
- Download full text (pdf) of Real-world clinical characterization, healthcare resource utilization and productivity loss in chronic graft versus host patients exposed to extracorporeal photopheresis in Sweden
Part of Leukemia, p. 550-559, 2023
- DOI for Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children
- Download full text (pdf) of Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children
Part of Journal of Allergy and Clinical Immunology, p. 205-213, 2023
Prediction model for drug response of acute myeloid leukemia patients
Part of npj Precision Oncology, 2023
- DOI for Prediction model for drug response of acute myeloid leukemia patients
- Download full text (pdf) of Prediction model for drug response of acute myeloid leukemia patients
Part of Lipids in Health and Disease, 2023
- DOI for Autologous hematopoietic stem cell transplantation significantly alters circulating ceramides in peripheral blood of relapsing-remitting multiple sclerosis patients
- Download full text (pdf) of Autologous hematopoietic stem cell transplantation significantly alters circulating ceramides in peripheral blood of relapsing-remitting multiple sclerosis patients
Part of Journal of Allergy and Clinical Immunology, p. 1706-1717, 2023
- DOI for European Competence Network on Mastocytosis (ECNM): 20-Year Jubilee, Updates, and Future Perspectives
- Download full text (pdf) of European Competence Network on Mastocytosis (ECNM): 20-Year Jubilee, Updates, and Future Perspectives
Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia
Part of Upsala Journal of Medical Sciences, 2023
- DOI for Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia
- Download full text (pdf) of Increased levels of a subset of angiogenesis-related plasma proteins in essential thrombocythemia
Part of Transplantation Proceedings, p. 242-248, 2023
- DOI for Worries and Psychological Well-Being in Potential Hematopoietic Stem Cell Donors Before Donation-A Swedish National Study
- Download full text (pdf) of Worries and Psychological Well-Being in Potential Hematopoietic Stem Cell Donors Before Donation-A Swedish National Study
Part of PLOS ONE, 2023
- DOI for Anti-Müllerian hormone and pregnancy after autologous hematopoietic stem cell transplantation for multiple sclerosis
- Download full text (pdf) of Anti-Müllerian hormone and pregnancy after autologous hematopoietic stem cell transplantation for multiple sclerosis
Improving prognostication and treatment choices for patients with AML
2023
Part of Nucleic Acids Research, 2022
- DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
- Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Part of Nature Biotechnology, p. 488-498, 2022
- DOI for T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
- Download full text (pdf) of T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Part of Frontiers in Medicine, 2022
- DOI for A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias
- Download full text (pdf) of A Study Protocol for Validation and Implementation of Whole-Genome and -Transcriptome Sequencing as a Comprehensive Precision Diagnostic Test in Acute Leukemias
Charting hematopoiesis in the single-cell omics era
Part of Journal of Allergy and Clinical Immunology, p. 785-787, 2022
Part of Journal of Sleep Research, 2022
- DOI for Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
- Download full text (pdf) of Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.