Molecular Precision Medicine
![A row of pipette heads in a pipetting machine.](/images/200.cb17a901900fe59989d2f/1718265347236/_MG_5856_1932x828.jpg)
Welcome to the research group in Molecular Precision Medicine. Our research is focused on genomics and epigenomics in human diseases.
Description of our research
The research group in Molecular Precision Medicine (MPM), headed by Dr. Jessica Nordlund, was started in 2020. The MPM research group develops and applies novel molecular approaches to analyze the genomes, transcriptomes, epigenomes and proteomes of clinical samples. By integrating multiple types of -omics data with machine learning, we aim to identify molecular biomarkers that distinguish a given patient from other patients with similar clinical presentations, improve the precision of molecular diagnoses, and identify novel treatment approaches.
Read the Childhood Cancer Foundation's interview with Jessica Nordlund
![Group picture of the members of the Molecular Precision Medicine research group.](/images/200.7630b4f918f153429f71445f/1714333625799/Gruppbild_618x412.jpg)
Members of the Molecular Precision Medicine research group.
Publications
Multi-modal single cell sequencing of B cells in primary Sjögren's Syndrome.
Part of Arthritis & Rheumatology, p. 255-267, 2024
- DOI for Multi-modal single cell sequencing of B cells in primary Sjögren's Syndrome.
- Download full text (pdf) of Multi-modal single cell sequencing of B cells in primary Sjögren's Syndrome.
An endothelial regulatory module links blood pressure regulation with elite athletic performance
Part of PLOS Genetics, 2024
- DOI for An endothelial regulatory module links blood pressure regulation with elite athletic performance
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Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Part of NAR Genomics and Bioinformatics, 2024
- DOI for Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
- Download full text (pdf) of Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
A multiomic characterization of the leukemia cell line REH using short- and long-read sequencing
Part of Life Science Alliance, 2024
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Part of Clinical Epigenetics, 2024
- DOI for Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
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Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
Part of Genes, Chromosomes and Cancer, p. 597-606, 2023
- DOI for Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
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Long-read whole-genome analysis of human single cells
Part of Nature Communications, 2023
- DOI for Long-read whole-genome analysis of human single cells
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Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Part of npj Precision Oncology, 2023
- DOI for Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
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Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies
Part of EBioMedicine, 2023
- DOI for Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies
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Genomic, transcriptomic and epigenomic sequencing data of the B-cell leukemia cell line REH
Part of BMC Research Notes, 2023
- DOI for Genomic, transcriptomic and epigenomic sequencing data of the B-cell leukemia cell line REH
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Part of Genome Biology, 2023
- DOI for Quartet DNA reference materials and datasets for comprehensively evaluating germline variant calling performance
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Part of Frontiers in Oncology, 2023
- DOI for Feasibility to use whole-genome sequencing as a sole diagnostic method to detect genomic aberrations in pediatric B-cell acute lymphoblastic leukemia
- Download full text (pdf) of Feasibility to use whole-genome sequencing as a sole diagnostic method to detect genomic aberrations in pediatric B-cell acute lymphoblastic leukemia
Part of Scientific Reports, p. 16261, 2023
- DOI for Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.
- Download full text (pdf) of Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma.
Part of PLOS Genetics, 2022
- DOI for Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
- Download full text (pdf) of Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
Part of Arthritis & Rheumatology, p. 1440-1450, 2022
- DOI for Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases
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Part of Frontiers in Molecular Biosciences, 2022
- DOI for Tackling the translational challenges of multi-omics research in the realm of European personalised medicine: A workshop report
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scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation
Part of Scientific Reports, 2022
- DOI for scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation
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Part of Genes, Chromosomes and Cancer, p. 27-36, 2022
- DOI for Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology
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Variants in BANK1 are associated with lupus nephritis of European ancestry.
Part of Genes and Immunity, p. 194-202, 2021
- DOI for Variants in BANK1 are associated with lupus nephritis of European ancestry.
- Download full text (pdf) of Variants in BANK1 are associated with lupus nephritis of European ancestry.
Contributions of de novo variants to systemic lupus erythematosus
Part of European Journal of Human Genetics, p. 184-193, 2021
- DOI for Contributions of de novo variants to systemic lupus erythematosus
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Part of Cancer Medicine, p. 3997-4003, 2021
- DOI for RAG1 co-expression signature identifies ETV6-RUNX1-like B-cell precursor acute lymphoblastic leukemia in children
- Download full text (pdf) of RAG1 co-expression signature identifies ETV6-RUNX1-like B-cell precursor acute lymphoblastic leukemia in children
Single nucleus transcriptomics data integration recapitulates the major cell types in human liver
Part of Hepatology Research, p. 233-238, 2021
- DOI for Single nucleus transcriptomics data integration recapitulates the major cell types in human liver
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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
Part of Cellular and Molecular Life Sciences (CMLS), p. 4019-4033, 2021
- DOI for Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
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Part of Nature Biotechnology, p. 1151-1160, 2021
The SEQC2 epigenomics quality control (EpiQC) study
Part of Genome Biology, 2021
- DOI for The SEQC2 epigenomics quality control (EpiQC) study
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DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome
Part of Frontiers in Immunology, 2021
- DOI for DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome
- Download full text (pdf) of DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren's Syndrome
Part of Genes, 2021
- DOI for DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
- Download full text (pdf) of DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99
Part of Scientific Reports, 2021
- DOI for Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99
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Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis
Part of Pathology, p. 875-882, 2021
- DOI for Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis
- Download full text (pdf) of Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis
Part of Annals of the Rheumatic Diseases, p. 109-117, 2021
- DOI for Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
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Part of Scientific Reports, 2021
- DOI for Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia
- Download full text (pdf) of Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia
Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing
Part of Nature Biotechnology, p. 1141-1150, 2021
Part of Scientific Data, 2021
- DOI for Whole genome and exome sequencing reference datasets from a multi-center and cross-platform benchmark study
- Download full text (pdf) of Whole genome and exome sequencing reference datasets from a multi-center and cross-platform benchmark study
Part of BMC Biology, 2020
- DOI for Genome assembly of the basket willow, Salix viminalis, reveals earliest stages of sex chromosome expansion
- Download full text (pdf) of Genome assembly of the basket willow, Salix viminalis, reveals earliest stages of sex chromosome expansion
Recent advances in single-molecule fluorescence microscopy render structural biology dynamic
Part of Current opinion in structural biology, p. 61-68, 2020
- DOI for Recent advances in single-molecule fluorescence microscopy render structural biology dynamic
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Part of RMD Open, 2020
- DOI for Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren's syndrome
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The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
Part of NATURE CANCER, p. 1066-1081, 2020
Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia
Part of Scientific Reports, 2020
- DOI for Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia
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Part of Leukemia and Lymphoma, p. 604-613, 2020
- DOI for Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia
- Download full text (pdf) of Overexpression of chromatin remodeling and tyrosine kinase genes in iAMP21-positive acute lymphoblastic leukemia
Part of PLOS Genetics, 2020
- DOI for Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling
- Download full text (pdf) of Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling
Chapter Eleven: Advances in whole genome methylomic sequencing
Part of Epigenetics Methods, p. 213-233, 2020
Part of Scientific Reports, 2020
- DOI for Refined detection and phasing of structural aberrations in pediatric acute lymphoblastic leukemia by linked-read whole-genome sequencing
- Download full text (pdf) of Refined detection and phasing of structural aberrations in pediatric acute lymphoblastic leukemia by linked-read whole-genome sequencing
Part of Annals of the Rheumatic Diseases, p. 363-369, 2020
- DOI for High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
- Download full text (pdf) of High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
Part of Blood, p. 2319-2333, 2020
Part of Human Genetics, p. 141-150, 2019
- DOI for Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
- Download full text (pdf) of Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
Part of British Journal of Haematology, p. 418-423, 2019
Arteria: An automation system for a sequencing core facility
Part of GigaScience, 2019
- DOI for Arteria: An automation system for a sequencing core facility
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Part of European Journal of Human Genetics, p. 432-441, 2019
- DOI for A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
- Download full text (pdf) of A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
Part of Frontiers in Immunology, 2019
- DOI for Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
- Download full text (pdf) of Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Part of Frontiers in Immunology, 2019
- DOI for Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome
- Download full text (pdf) of Shared and Unique Patterns of DNA Methylation in Systemic Lupus Erythematosus and Primary Sjogren's Syndrome