Transplantation and Regenerative Medicine
![Insulin-producing cells in green together with growing blood vessels in red after experimental transplantation to muscle.](/images/200.4ae81edf18e5f70c02a3ace4/1712068790550/Islets%20in%20muscle_1932x828.jpg)
Insulin-producing cells in green derived from induced pluripotent stem cells. Growing blood vessels in red after experimental transplantation to muscle.
The overall goal of the research group is to prevent the development of type I diabetes, and to use cell therapy to normalise glucose metabolism in patients with type I diabetes.
The research group is located at both the Department of Medical Cell Biology and the Department of Medical Sciences, which facilitates the transfer of experimental results to clinical use.
Mechanistic experimental studies are conducted to investigate, among other things, the ability of stem cell-derived insulin-producing cells to adapt to new environments after transplantation to different organs, and how to improve the safety, survival and function of the graft.
Clinical studies are testing the possibility of using cell therapy to stop the loss of own insulin-producing cells in the development of type 1 diabetes, and how insulin-producing cells can be transplanted without the need for immunosuppressive treatment. Other clinical studies are developing image analysis techniques to non-invasively monitor changes in the number of insulin-producing cells and the immune attack in the pancreas during the development of type 1 diabetes.
Publications
Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2024
- DOI for Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetes
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Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
Part of JAMA Network Open, 2024
- DOI for Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults
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Part of Chest, p. 503-516, 2023
- DOI for OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study
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Classification of Hypoglycemic Events in Type 1 Diabetes Using Machine Learning Algorithms
Part of Diabetes Therapy, p. 953-965, 2023
Part of Free radical research, p. 460-469, 2023
- DOI for The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
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Part of Cell Stem Cell, p. 38-51, 2023
- DOI for An insulin hypersecretion phenotype precedes pancreatic beta cell failure in MODY3 patient-specific cells
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Part of BMC Medical Informatics and Decision Making, 2023
- DOI for Development and usability evaluation of an electronic health report form to assess health in young people: a mixed-methods approach
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Part of Obesity, p. 1755-1766, 2023
- DOI for Exposure to a more unhealthy diet impacts sleep microstructure during normal sleep and recovery sleep: A randomized trial
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A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
Part of Journal of Sleep Research, 2023
- DOI for A weighted blanket increases pre-sleep salivary concentrations of melatonin in young, healthy adults
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Part of Translational Psychiatry, p. 32, 2023
- DOI for Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals.
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Part of Journal of Sleep Research, 2022
- DOI for Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
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Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2022
- DOI for Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes
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Part of BMJ Open Diabetes Research & Care, 2022
- DOI for Higher risk of severe hypoglycemia in children and adolescents with a rapid loss of C-peptide during the first 6 years after type 1 diabetes diagnosis
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Part of International Journal of Developmental Neuroscience, p. 407-422, 2022
Part of Behavioural Pharmacology, p. 575-588, 2022
Part of Frontiers in Nutrition, 2022
- DOI for Association of Daily Eating Duration and Day-To-Day Variability in the Timing of Eating With Fatal Cancer Risk in Older Men
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Part of JMIR Diabetes, 2022
Could a good night's sleep improve COVID-19 vaccine efficacy?
Part of The Lancet Respiratory Medicine, p. 447-448, 2021
Part of Clocks & Sleep, p. 251-258, 2021
- DOI for Meal and Sleep Timing before and during the COVID-19 Pandemic: A Cross-Sectional Anonymous Survey Study from Sweden
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Part of Nature and Science of Sleep, p. 1711-1722, 2021
- DOI for Social Jetlag Changes During the COVID-19 Pandemic as a Predictor of Insomnia - A Multi-National Survey Study
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Part of Sleep and Breathing, p. 849-860, 2021
Part of Peptides, 2021
- DOI for CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats
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Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
Part of Biomedicines, 2021
- DOI for Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
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Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes
Part of Diabetes, p. 966-975, 2021
GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
Part of BMJ Open Diabetes Research & Care, 2021
- DOI for GABA induces a hormonal counter-regulatory response in subjects with long-standing type 1 diabetes
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NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
Part of Nature Metabolism, p. 1621-1632, 2021
- DOI for NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding
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Part of International Journal of Molecular Sciences, 2021
- DOI for Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells
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Part of Sleep, 2021
- DOI for Evening-types show highest increase of sleep and mental health problems during the COVID-19 pandemic - Multinational study on 19,267 adults.
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Insomnia, anxiety, and depression during the COVID-19 pandemic: an international collaborative study
Part of Sleep Medicine, p. 38-45, 2021
Gut microbiome as a therapeutic target in the treatment of sleep disorders: where we are
Part of Sleep Medicine Reviews, 2021
Part of BMJ Open, 2021
- DOI for Sleep and daytime problems during the COVID-19 pandemic and effects of coronavirus infection, confinement and financial suffering: a multinational survey using a harmonised questionnaire
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Part of International Journal of Developmental Neuroscience, p. 616-632, 2021
Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
Part of Neurology, 2020
- DOI for Effects of acute sleep loss on diurnal plasma dynamics of CNS health biomarkers in young men
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Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
Part of Cell Transplantation, p. 1-10, 2020
- DOI for Function and Gene Expression of Islets Experimentally Transplanted to Muscle and Omentum
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Part of BMJ Open Diabetes Research & Care, 2020
- DOI for Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later
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Part of Journal of Clinical Endocrinology and Metabolism, 2020
- DOI for Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
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NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging
Part of Molecular Cell, p. 835-+, 2020
Part of Frontiers in Immunology, 2020
- DOI for Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets
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Part of Frontiers in Nutrition, 2020
- DOI for Abdominal Fat and Metabolic Health Markers but Not PNPLA3 Genotype Predicts Liver Fat Accumulation in Response to Excess Intake of Energy and Saturated Fat in Healthy Individuals
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Part of Scientific Reports, 2020
- DOI for Self-reported difficulty initiating sleep and early morning awakenings are associated with nocturnal diastolic non-dipping in older white Swedish men
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Part of Physiological Reports, 2020
- DOI for Highly blood perfused, highly metabolically active pancreatic islets may be more susceptible for immune attack
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An epigenetic clock for human skeletal muscle
Part of Journal of Cachexia, Sarcopenia and Muscle, p. 887-898, 2020
- DOI for An epigenetic clock for human skeletal muscle
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Part of Upsala Journal of Medical Sciences, p. 228-237, 2019
- DOI for Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.
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Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron
Part of Cell Metabolism, p. 1078-109100000, 2019
Ghrelin in rat pancreatic islets decreases islet blood flow
Part of American Journal of Physiology. Endocrinology and Metabolism, 2019
Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
Part of International Journal of Molecular Sciences, 2019
- DOI for Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes.
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Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI
Part of Acta Diabetologica, p. 1113-1120, 2019
- DOI for Pancreatic perfusion and its response to glucose as measured by simultaneous PET/MRI
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Pancreatic Blood Flow with Special Emphasis on Blood Perfusion of the Islets of Langerhans
Part of COMPREHENSIVE PHYSIOLOGY, p. 799-837, 2019
Unsurpassed Intrahepatic Islet Engraftment: the Quest for New Sites for Beta Cell Replacement
Part of Cell Medicine, 2019
- DOI for Unsurpassed Intrahepatic Islet Engraftment: the Quest for New Sites for Beta Cell Replacement
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Part of Cell Transplantation, p. 1455-1460, 2019
- DOI for Fewer Islets Survive from a First Transplant than a Second Transplant: Evaluation of Repeated Intraportal Islet Transplantation in Mice
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