Clinical Diabetes and Metabolism
![Close-up of a medical professional drawing blood from a finger.](/images/200.4ae81edf18e5f70c02a467e8/1712298052465/Klinisk%20diabetologi%20och%20metabolism_1932x828.jpg)
The research carried out within the research group Clinical Diabetology and Metabolism aims to enhance understanding of disease mechanisms and to improve prevention and treatment of type 2 diabetes and obesity. In addition, consequences of diabetes are elucidated, and this includes medical complications as well as the patients’ care and their experiences. Our research is performed in close collaboration with national and international networks, including an EU-Horizon consortium.
Description of our research
The Clinical Diabetes and Metabolism research group is divided into two subgroups where one group focuses on research related to the prevention and treatment of type 2 diabetes and obesity while the other group focuses on diabetes care.
New ways to prevent and treat type 2 diabetes and obesity
Principal Investigator: Prof Jan Eriksson
Understanding disease development
We perform studies involving healthy volunteers and patients. Samples of blood and tissues are analysed to unravel mechanisms at the cell and molecular levels, which contribute to development of type 2 diabetes or obesity. We also monitor nutrient turnover in the whole body during different conditions or after treatments. In such investigations, advanced imaging techniques such as PET and MRI measurements are often utilized. A major focus of this part of the research to understand the importance of different organs and their interactions, for example brain, fat, gut, and liver as well as various hormone systems.
Novel prevention and treatment strategies
We are involved in several intervention projects. They test new concepts to prevent or reverse obesity, type 2 diabetes, and their complications. These studies evaluate effects of medicines, diets, behaviour and even surgery. In the long term, we anticipate proposing methods to tailor the best treatment to the individual in a personalized manner. This will be achieved by using both new diagnostic tools and new pharmacological and non-pharmacological principles.
Ongoing projects in ways to prevent and treat type 2 diabetes and obesity
- SMARTEST – SGLT2-hämmare eller metformin som standardbehandling vid tidig diabetes Typ 2?
- PAS GRAS – De-Risking metabolic, environmental and behavior determinants of obesity in children, adolescents, and young adults
- Epidemiology of diabetes complications
- Neuroendocrine regulation of glucose homeostasis
- Metabolic and neuroendocrine effects of bariatric surgery
- Behavioural and molecular features of a rat model of diet-induced obesity
- Exploring the adipose tissue
- Immunometabolism and neuroendocrine mechanisms
Diabetes care
Principal Investigator: Janeth Leksell
- Assessing the impact of self-management programs on both type 1 and type 2 diabetes patients.
- Studying the health-related quality of life in type 2 diabetes patients at onset and during the first two years.
- Investigating the correlation between Diabetes Questionnaire responses and medical, sociodemographic, and comorbidity data.
- Evaluating patients' perspectives on participating in clinical trials in both rural and urban settings.
We focus on developing effective self-management educational programs for people with diabetes. Initial results from our virtual diabetes care study demonstrate its efficacy compared to physical meetings, with ongoing evaluation after 1 and 2 years. Additionally, we're testing an individual treatment plan for type 2 diabetes patients based on Dorothea Orem's self-care theory. This plan aims to enhance collaboration between patients and diabetes nurses and evaluate its impact on various health parameters and patient experiences.
Understanding patient satisfaction with care and treatment is crucial. Our SMARTEST project investigates the quality of life in early-stage type 2 diabetes patients over one and two years, considering medication treatment, socioeconomic status, and demographic factors.
Collaborating with the National Diabetes Register, we've developed a digital Diabetes Questionnaire for routine clinical visits, allowing patient perspectives to be integrated into care. We're exploring its association with medical data and sociodemographic factors.
In long-term studies, we explore factors influencing patients' perspectives on participating in clinical trials, conducting interviews in rural and urban areas to develop a model for clinical trial implementation, particularly focusing on Gotland.
Ongoing projects in diabetes care
Our research focus is to describe and to evaluate interventions that are based on capturing and illuminating the patient's perspective of living with a chronic disease such as diabetes. Since diabetes is a serious lifelong disease, it is important to find interventions that support persons to a healthy lifestyle. Persons with diabetes experience a need for an encouraging patient-professional relationship that inspires them to be leader of their own self-management. Pharmacological treatment itself may affect the quality of life. If health-related life quality (HRLQ) is reduced by treatment, compliance might be affected, altering glycemic control and the risk of complications. Patient-related outcome measures (PROMs), such as HRLQ and treatment satisfaction incorporates patient perspectives into healthcare decision making.
Publications
Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells
Part of Biomolecules, 2024
- DOI for Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells
- Download full text (pdf) of Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells
CD8+Treg cells play a role in the obesity-associated insulin resistance
Part of Life Sciences, 2024
- DOI for CD8+Treg cells play a role in the obesity-associated insulin resistance
- Download full text (pdf) of CD8+Treg cells play a role in the obesity-associated insulin resistance
Part of EBioMedicine, 2024
- DOI for CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation
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Part of BMC Musculoskeletal Disorders, 2024
- DOI for Incidence and sequence of scoliosis and windswept hip deformity: which comes first in 4148 children with cerebral palsy? A longitudinal cohort study
- Download full text (pdf) of Incidence and sequence of scoliosis and windswept hip deformity: which comes first in 4148 children with cerebral palsy? A longitudinal cohort study
Part of Sexual & Reproductive HealthCare, 2024
- DOI for Instrument development and an intervention to increase parents' self-efficacy regarding their infant's sleep
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Part of Health Promotion International, 2024
- DOI for Health literacy and its association with mental and spiritual well-being among women experiencing homelessness
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Sämre livskvalitet bland kvinnor med gynekologisk cancer födda utomlands
Part of Läkartidningen, 2024
Part of Scandinavian Journal of Caring Sciences, p. 82-91, 2024
- DOI for I have never been invited-A cross-sectional explorative study of family members' experiences of encounters with healthcare professionals in diabetes care
- Download full text (pdf) of I have never been invited-A cross-sectional explorative study of family members' experiences of encounters with healthcare professionals in diabetes care
Part of Journal of Clinical Endocrinology and Metabolism, 2024
- DOI for Regulation of the Cortisol Axis, Glucagon, and Growth Hormone by Glucose Is Altered in Prediabetes and Type 2 Diabetes
- Download full text (pdf) of Regulation of the Cortisol Axis, Glucagon, and Growth Hormone by Glucose Is Altered in Prediabetes and Type 2 Diabetes
Part of Journal of Diabetes Science and Technology, p. 89-98, 2024
- DOI for Evaluation of Effects of Continuous Glucose Monitoring on Physical Activity Habits and Blood Lipid Levels in Persons With Type 1 Diabetes Managed With MDI: An Analysis Based on the GOLD Randomized Trial (GOLD 8)
- Download full text (pdf) of Evaluation of Effects of Continuous Glucose Monitoring on Physical Activity Habits and Blood Lipid Levels in Persons With Type 1 Diabetes Managed With MDI: An Analysis Based on the GOLD Randomized Trial (GOLD 8)
Part of Quality of Life Research, p. 667-678, 2024
- DOI for Differences in health-related quality of life between native and foreign-born gynaecological cancer patients in Sweden: a five-year cross-sectional study
- Download full text (pdf) of Differences in health-related quality of life between native and foreign-born gynaecological cancer patients in Sweden: a five-year cross-sectional study
Subcutaneous adipose tissue dopamine D2 receptor expression is increased in prediabetes and T2D
Part of Endocrine, 2024
- DOI for Subcutaneous adipose tissue dopamine D2 receptor expression is increased in prediabetes and T2D
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Part of Endocrinology, 2023
- DOI for Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women
- Download full text (pdf) of Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women
Part of Scandinavian journal of urology, p. 67-74, 2023
- DOI for Predictive characteristics for disease recurrence and overall survival in non-metastatic clinical T1 renal cell carcinoma: results from the National Swedish Kidney Cancer Register
- Download full text (pdf) of Predictive characteristics for disease recurrence and overall survival in non-metastatic clinical T1 renal cell carcinoma: results from the National Swedish Kidney Cancer Register
Part of Midwifery, 2023
- DOI for Breastfeeding training improved healthcare professional's self-efficacy to provide evidence-based breastfeeding support: A pre-post intervention study
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Classification of Hypoglycemic Events in Type 1 Diabetes Using Machine Learning Algorithms
Part of Diabetes Therapy, p. 953-965, 2023
Part of Endocrine Connections, 2023
- DOI for Altered glucose-dependent secretion of glucagon and ACTH is associated with insulin resistance, assessed by population analysis
- Download full text (pdf) of Altered glucose-dependent secretion of glucagon and ACTH is associated with insulin resistance, assessed by population analysis
Part of Metabolites, 2023
- DOI for Several Metabolite Families Display Inflexibility during Glucose Challenge in Patients with Type 2 Diabetes: An Untargeted Metabolomics Study
- Download full text (pdf) of Several Metabolite Families Display Inflexibility during Glucose Challenge in Patients with Type 2 Diabetes: An Untargeted Metabolomics Study
Effects of gastric bypass surgery on brain connectivity responses to hypoglycemia
Part of Endocrine, p. 304-312, 2023
- DOI for Effects of gastric bypass surgery on brain connectivity responses to hypoglycemia
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Part of Diabetes, obesity and metabolism, 2023
- DOI for Associations of bolus insulin injection frequency and smart pen engagement with glycaemic control in people living with type 1 diabetes
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Part of Adipocyte, 2023
- DOI for CABLES1 expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism
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Part of Experimental and clinical endocrinology & diabetes, p. 236-241, 2023
- DOI for Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in management of Graves' orbitopathy
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Vitamin D and bone metabolism in Graves’ disease: a prospective study
Part of Journal of Endocrinological Investigation, p. 425-433, 2023
- DOI for Vitamin D and bone metabolism in Graves’ disease: a prospective study
- Download full text (pdf) of Vitamin D and bone metabolism in Graves’ disease: a prospective study
Virtual clinic for young people with type 1 diabetes: a randomised wait-list controlled study
Part of BMC Endocrine Disorders, 2023
- DOI for Virtual clinic for young people with type 1 diabetes: a randomised wait-list controlled study
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Part of Diabetes & Vascular Disease Research, 2023
- DOI for Health care registers can be instrumental for endpoint capture in clinical diabetes trials: example of microvascular complications in Swedish patients with type 2 diabetes
- Download full text (pdf) of Health care registers can be instrumental for endpoint capture in clinical diabetes trials: example of microvascular complications in Swedish patients with type 2 diabetes
Glucose-dependent inflammatory responses in obese compared to lean individuals
Part of Endocrine, p. 464-476, 2023
- DOI for Glucose-dependent inflammatory responses in obese compared to lean individuals
- Download full text (pdf) of Glucose-dependent inflammatory responses in obese compared to lean individuals
Maskininlärning användes för att förbättra upptäckt av tarmcancer
Part of Läkartidningen, 2023
A machine learning tool for identifying non-metastatic colorectal cancer in primary care
Part of European Journal of Cancer, p. 100-106, 2023
- DOI for A machine learning tool for identifying non-metastatic colorectal cancer in primary care
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Transforming early cancer detection in primary care: harnessing the power of machine learning
Part of Oncoscience, p. 20-21, 2023
- DOI for Transforming early cancer detection in primary care: harnessing the power of machine learning
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Validation of a diagnostic prediction tool for colorectal cancer: a case–control replication study
Part of Family Practice, 2023
- DOI for Validation of a diagnostic prediction tool for colorectal cancer: a case–control replication study
- Download full text (pdf) of Validation of a diagnostic prediction tool for colorectal cancer: a case–control replication study
Part of Cytokine, 2023
- DOI for Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes
- Download full text (pdf) of Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes
Part of Journal of Diabetes Science and Technology, 2023
- DOI for Treatment Satisfaction and Well-Being With CGM in People With T1D: An Analysis Based on the GOLD Randomized Trial
- Download full text (pdf) of Treatment Satisfaction and Well-Being With CGM in People With T1D: An Analysis Based on the GOLD Randomized Trial
Part of Clinical Obesity, 2023
- DOI for Complementary elements of support after gastric-bypass surgery perceived by adults with previous type 2 diabetes: A qualitative study 2 years after bariatric surgery
- Download full text (pdf) of Complementary elements of support after gastric-bypass surgery perceived by adults with previous type 2 diabetes: A qualitative study 2 years after bariatric surgery
Part of BMJ Open, 2023
- DOI for History of heart failure and chronic kidney disease and risk of all-cause death after COVID-19 during the first three waves of the pandemic in comparison with influenza outbreaks in Sweden: a registry-based, retrospective, case-control study
- Download full text (pdf) of History of heart failure and chronic kidney disease and risk of all-cause death after COVID-19 during the first three waves of the pandemic in comparison with influenza outbreaks in Sweden: a registry-based, retrospective, case-control study
Part of Clinical Nutrition, p. 2554-2561, 2023
- DOI for Long-term association between malnutrition and all-cause mortality among older adults: A 10-years follow-up study
- Download full text (pdf) of Long-term association between malnutrition and all-cause mortality among older adults: A 10-years follow-up study
Part of NMR in Biomedicine, 2023
Part of Molecular and Cellular Endocrinology, 2023
- DOI for Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation
- Download full text (pdf) of Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation
Part of Journal of Clinical Immunology, p. 1-9, 2022
- DOI for X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia
- Download full text (pdf) of X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia
Part of Obesity Surgery, p. 2468-2468, 2022
Part of Adipocyte, p. 434-447, 2022
- DOI for ESR2 expression in subcutaneous adipose tissue is related to body fat distribution in women, and knockdown impairs preadipocyte differentiation
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Part of Journal of Clinical Endocrinology and Metabolism, 2022
- DOI for Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women
- Download full text (pdf) of Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women
Part of Nucleic Acids Research, 2022
- DOI for Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
- Download full text (pdf) of Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ
Part of JN. Journal of Nephrology, p. 493-503, 2022
- DOI for Estimation of kidney function in patients with primary neuromuscular diseases: is serum cystatin C a better marker of kidney function than creatinine?
- Download full text (pdf) of Estimation of kidney function in patients with primary neuromuscular diseases: is serum cystatin C a better marker of kidney function than creatinine?
Part of Journal of Sleep Research, 2022
- DOI for Acute sleep loss alters circulating fibroblast growth factor 21 levels in humans: A randomised crossover trial.
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Part of Disability and Rehabilitation, p. 6738-6743, 2022
- DOI for Relationship between scoliosis, windswept hips and contractures with pain and asymmetries in sitting and supine in 2450 children with cerebral palsy
- Download full text (pdf) of Relationship between scoliosis, windswept hips and contractures with pain and asymmetries in sitting and supine in 2450 children with cerebral palsy
Part of Disability and Rehabilitation, p. 2363-2371, 2022
- DOI for Postural asymmetries, pain, and ability to change position of children with cerebral palsy in sitting and supine: a cross-sectional study
- Download full text (pdf) of Postural asymmetries, pain, and ability to change position of children with cerebral palsy in sitting and supine: a cross-sectional study
Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Part of Cell Reports Medicine, 2022
- DOI for Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
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Special Issue on Metabolism and Metabolite Markers in Type 2 Diabetes
Part of Metabolites, 2022
- DOI for Special Issue on Metabolism and Metabolite Markers in Type 2 Diabetes
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Response of multiple hormones to glucose and arginine challenge in T2DM after gastric bypass
Part of Endocrine Connections, 2022
- DOI for Response of multiple hormones to glucose and arginine challenge in T2DM after gastric bypass
- Download full text (pdf) of Response of multiple hormones to glucose and arginine challenge in T2DM after gastric bypass
Part of Metabolism, 2022
- DOI for Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
- Download full text (pdf) of Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
Are you interested in our work and would like to join?
We recruit study volunteers all year round! We recruit people above the age of 18, both with and without type 2 diabetes.
If you would like to know more about what we do and you are interested in becoming part of our research, contact us at diabetesforskning@akademiska.se, or contact Sofia Löfving, group leader, 018-611 35 71.
Additional resources
- Uppsala Diabetes Centre (UDC)
- Endocrine and diabetes clinic at Akademiska sjukhuset
- Danish Diabetes and Endocrine Academy (DDEA)
- German Center for Diabetes Research (DZD)
- Swedish National Diabetes Register
- Swedish Diabetes Association
- European Association for the Study of Diabetes
- Diabeteshandboken
- Dagens medicin news on type 2 diabetes (only in Swedish)
- Dagens medicin news on obesity (only in Swedish)