Brain tumors and skull base surgery
The main goal is the continuous research of a better treatment for patients with brain tumors. The aim is to better understand how the brain and the tumors interact at the individual level to develop new techniques to reduce the functional cost of neurosurgical operation and to help find new treatment strategies.
Project description
We have an established multimodal approach to research on brain tumors. We have a better anatomical knowledge through the study of white matter bundles at the Bio-Medicinsk Centrum and advanced neuroimaging such as tractography and functional MRI; we have a unique preoperative strategy focused on the assessment and follow-up of cognitive functions with a central role for neuropsychologists and speech therapist; we have an incredible development of intraoperative monitoring techniques in both awake and asleep surgeries able to reduce the risk of postoperative symptoms. In the last years we have also developed a unique cooperation with Clinical Pharmacology and Rudbeck Laboratory. We can now analyze tumor sample with multimodal approach trying to identify new treatment modalities based on tumor cell resistance to oncological treatment and intratumoral heterogeneity. We are also part of large multicentric studies and database for the quality development of management of brain tumors.
Examples of studies:
- Neurosurgical anatomy studies of the brain's white pathway system and development of a new classification system for glioma.
- Mapping of symptoms and impact on higher functions in patients with glioma.
- Beyond Observed Lesion Diameter (BOLD) glioblastoma surgery: a multicenter randomized controlled trial.
- Treatment resistance in patients with glioblastoma: implications for postoperative strategy.
- Understanding heterogeneity and tumor relapse in glioblastoma.
- Multimodal mapping of intratumoral differences in patients with glioma.
- Investigating differences between grade 2 and grade 3 gliomas: White matter anatomy, clinical aspects, surgical implications, and oncological outcome.
- Multicentric study on neuropsychological and cognitive aspects in patients with diffuse glioma.
- Investigating multimodal hallmarks among suspected diffuse low-grade gliomas: A multicentric Scandinavian database study.
- Evaluation of the neurosurgical treatment of craniopharyngiomas in Sweden.
- Biological, functional and cosmetic follow-up of cranioplasty procedures.